SET Nuclear Oncogene Associates with Microcephalin/MCPH1 and Regulates Chromosome Condensation
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چکیده
منابع مشابه
SET nuclear oncogene associates with microcephalin/MCPH1 and regulates chromosome condensation.
Primary microcephaly is an autosomal recessive disorder characterized by marked reduction in human brain size. Microcephalin (MCPH1), one of the genes mutated in primary microcephaly, plays an important role in DNA damage checkpoint control and mitotic entry. Additionally, MCPH1 ensures the proper temporal activation of chromosome condensation during mitosis, by acting as a negative regulator o...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2011
ISSN: 0021-9258
DOI: 10.1074/jbc.m110.208793